Cancer Detection and Prevention Volume 18 / Issue 5 (Sep-Oct 1994)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Human T-Lymphotropic Virus Type-I Influence on Hepatotropic Virus Infections and the Subsequent Development of Hepatocellular Carcinoma

Shimeru Kamihira, MD, Yasuaki Yamada, MD, Hisasi Sohda, MD, Sunao Atogami, MD, Masao Tomonaga, MD, Satoko Egawa, Minoru Fujii, Kousaburou Chifu, MD

In serologic studies of hepatitis B virus (HBV), hepatitis C virus (HCV) and human T-lymphotrophic virus type-1 (HTLV-1) of blood donors in an endemic area of adult T-cell leukemia (ATL) the presence of anti-HCV correlated with positive HTLV- 1 status. It is suggested that HTLV-1 may act as a cofactor in the development of HCC caused by hepatotropic viruses. >>>

Multistep Alterations of Human Lymphocytes Infected with HTLV-I and Then Exposed to Carcinogens

Shigenobu Mochizuki, PhD, Tokunin Fukushima, PhD, Koshi Maruyama, MD, PhD

HTLV-1 infection of normal human lymphocytes led to chromosomal abnormalities and continuous cell growth in IL-2 containing medium. Subsequent exposure to N-methyl-N'- nitroso-guanidine (MNNG) and TPA or UV produced cell transformation with autonomous growth and additional chromosomal abnormalities. >>>

Correlation Between Family History of Colorectal Cancer and Pathological and Clinical Features of the Disease

H Aste, MD, M Picasso, MD, A Allegretti, MD, M Conio, MD

A positive family history of first degree relatives with cancer existed in 171 of 461 patients with colorectal cancer; 52 had cancer of the large intestine while 119 had tumors of the lung, stomach, breast, uterus and other extracolonic solid and hematologic neoplasms. >>>

Lung Cancer in the Young

M Patricia Rocha, MD, Armando E Fraire, MD, Kalpalatha K Guntupalli, MD, S Donald Greenberg, MD

Fifty (2.98%) of 1678 patients with lung cancer were age 40 or less. A smoking history was available in 37 of the 50 patients. The most common histopathologic cell type was adenocarcinoma. >>>

Increased Levels of a 21-kDa protein in the Circulation of Tumor-Bearing Patients

Channa Shalitin, PhD, Ron Epelbaum, MD, Boaz Moskovitz, MD , Ruth Segal, BSC, Clari Valansi, BSc, Marina Werner, MD, Pinchas M Livne, MD

Sera from 124 patients and 43 healthy controls were tested by the enzyme-linked immunoabsorbent assay (ELISA) for a novel non-ras 21-KDa protein (p21). Elevated levels were present in 4.6% of healthy controls, in 78.2% of patients with renal cell carcinoma, in 66% with gastrointestinal cancer and in 77.7% with malignant lymphoma. In several patients a favorable response to therapy correlated with a decline in p21 serum levels. >>>

The Expression of HLA-DR Antigen in Cervical Neoplasia

GC Raju, MD, M Teh, MD, A Wee, MD

In 77 uterine cervical specimens that were studied immunohistochemically for HLA-DR antigen expression. The normal endocervical glands, squamous metaplastic eqithelium, CIN, and invasive carcinomas were HLA-DR antigen positive. >>>

Breast Imaging: A Comparison of Digital Luminescence Radiographs Displayed on TV-Monitor and Film-Screen Mammography

Olof Jarlman, MD, PhD, Anders Borg, MD, Marek Braw, MD, Mikael Kehler, MD, PhD, Kerstin Lyttkens, MD, Lars Samuelsson, MD, PhD

The evaluation of 100 digital mammograms displayed on a TV monitor produced promising results in comparision to diagnoses of conventional mammograms. >>>

Cell Type Identification in Leukemia: The Level of Agreement Among Four Independent Diagnostic Methods

Bernard CK Choi, MSc, PhD, Etienne de Harven, MD, Denis J Bailey, MD, Ian D Dube, MSc, PhD, Dominic Pantalony, MD

Identification of cell types in 23 blood and bone marrow specimens was studied by four diagnostic methods. Results of interpretation differed between routine morphology, electron microscopy, cell surface marker analysis, and cancer cytogenetics. >>>

Tumor Cell Kinetics Following Long-Term Treatment with Antineoplastic Ether Phospholipids

Paola Principe, PhD, Carole Sidoti, PhD, Helene Coulomb, PhD, Colette Broquet, PhD, DSc, Pierre Braquet, PhD, Dsc

The cytostatic effect of ether phospholipids, ET-18 OCH₃, BM41.440, BN52205, and BN52211 were evaluated by flowcytometry on human colon ademocarcinoma HT29 cell line. Cells treated in the G₁ phase progressed through S-phase and were blocked in G₂. When treated in the late G₂ phase, the cells progressed through the M phase and were blocked in G₁. >>>

Dietary Cottonseed Protein Can Reduce the Severity of Retinoid-Induced Hypertriglyceridemia

John D Radcliffe, PhD, Alana C Glass, BS

Cottonseed protein in the diet of male Fischer 344 rats reduced the severity of hypertriglyceridemia induced by feeding 13-cis-retinoic acid without adverse effects on food intake and growth. >>>

Multidrug Resistance Gene and P-Glycoprotein Expression in Anaplastic Carcinoma of the Thyroid

Tomoyuki Yamashita, MD, PhD, Masatoshi Watanabe, Masatomo Onodera, Katsutaro Shimaoka, MD, PhD, Kunihiko Ito, MD, PhD, Yoshihide Fujimoto, MD, PhD, Shinji Itoyama, MD, PhD, Isamu Sugawara, MD, PhD

In 20 specimens from 16 patients with anaplastic thyroid cancer, expression of the multidrug resistant gene (mdr1) and its gene product P-glycoprotein (p-GP) expression was not related to the chemotherapeutic response. Examination of mdr1 was made by reverse transcriptase and polymerase chain reaction. P-GP expression was evaluated by an immunohistochemical method using JSP-1 monoclonal antibody. >>>

Herbert E. Nieburgs, MD
Worcester, MA
1994