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Published in Cancer Detection and Prevention 1995; 19(1). Biological monitoring of petrochemical workers: chromosomal aberrations and sister-chromatid exchanges in blood lymphocytes1Dept. of Biological Sciences, Yarmouk University Irbid, Jordan, 2Hijjawi College for Applied Engineering, Yarmouk University, Irbid, Jordan, 3Health Dept. Jordan Petroleum Refinery Company, Zarka, Jordan.To assess the possible cytogenetic consequences of occupational exposure to petrochemicals, the frequencies of chromosomal aberrations (CA) and sister-chromatic exchanges (SCE) in cultured lymphocytes were studied. Blood was obtained from 233 individuals (184 exposed and 49 worksite control) in an oil refinery and from 47 community control persons. In all, data showed non-significant elevations in SCE and CA levels In exposed workers as compared to non-exposed individuals. The mean SCE frequency per cell ranged from 7.55 +/- 0.55 in blood of lube oil blending and canning workers to 9.13 +/- 0.71 in blood of workers in catalytic cracking and water treatment workshop. The control values were 6.20 +/- 0.67 and 7.21 +/- 0.45 in the community and worksite controls, respectively. In respect to CA, they occurred with frequencies between 0.023 +/- 0.013 and 0.037 +/- 0.011 break per cell (1.56 +/- 0.87 to 2.59 +/- 0.53% aberrant cells) in the exposed groups. In controls, the levels ranged from 0.015 +/- 0.007 to 0.021 +/- 0.012 break per cell and from 1.1 7 +/- 0.38 to 1.46 +/- 0.59% aberrant cells. In general, the cytogenetic effects were neither influenced by age nor by smoking. Paper presented at the International Symposium on the Impact of Biotechnology on Predictive Oncology and Therapy; Boston, Massachusetts; December 11 - 13, 1994; in the section on Exposure To Genotoxic Agents. |
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