Published in Cancer Detection and Prevention 1997; 21(5):418-425.

Immunohistochemical Detection of p53 Protein and Prognosis of Surgically Resected Non-Small-Cell Lung Cancer

Xavier Quantina, Jean-Louis Pujola, Michel Lehmannb, Joelle Simonyc, Isabelle Serred, and Francois-Bernard Michela

aService des Maladies Respiratoires, Centre Hospitalier Universitaire de Montpellier, Hopital Amaud de Villeneuve, Montpellier, France; bService des Statistiques Medicales, Centre Hospitalier Universitaire de Montpellier Nimes, Hospital Gaston Doumergue, Nimes, France; cCenter Anti-Cancer, Centre Hospitalier Universitaire de Montpellier, Centre Val d'Aurelle, Montpellier, France; dService d'Anatomie-Pathologique, Centre Hospitalier Universitaire de Montpellier, Hospital Lapeyronie, Montpellier, France

Address all correspondence and reprint requests to: Jean-Louis Pujol, Service de Maladies Respiratoires, Centre Hospitalier Universitaire de Montpellier. Hopital Arnaud de Villeneuve, 34295 Montpellier, Cedex, France.

ABSTRACT: We analyzed the survival of 89 surgically treated patients presenting non-small-cell lung cancer in regard to the accumulation of p53 protein as detected by indirect immunoperoxidase reactivity of PAb1801 anti-human p53 protein. Although the well-known factors such as stage grouping, tumor status, and nodal status were found to be prognostic determinants, the p53 protein accumulation had no effect on either univariate analysis or multivariate analysis of survival.

KEY WORDS: immunohistochemistry, non-small-cell lung cancer, p53, prognosis, surgery.