Published in Cancer Detection and Prevention 1998; 22(Supplement 1).

Tumor inhibition by several components extracted from Hedyotis corymbosa and Hedyotis diffusa

H Y Hsu PhD

Tzu-Chi College Medicine and Humanities, Department of Life Science, Taiwan

AIM: To investigate the key components exhibiting anti-tumor activities in two kinds of herbs, Hedyotis corymbosa and Hedyotis diffusa. METHODS: Implanted subcutaneous tumor and hepatoma cell line hep-2B are used to study the tumor-inhibitory effect of three components in Hedyotis corymbosa and Hedyotis diffusa, ursolic acid, oleanolic acid and geniposidic acid, through the gradient administration doses in vivo and in vitro, respectively. RESULTS: Among these drugs used to investigate their anti-tumor activities, ursolic acid and oleanolic acid are more prominent in inhibiting the growth of cultured hep-2B cells and the enlargement of subcutaneous tumor. In relative studies after treating with these drugs, ursolic acid and oleanolic acid also show a significant increase of immunocompetence of splenic cells as compared with that of geniposidic acid. CONCLUSIONS: There are probably some components existed in Hedyotis corymbosa and Hedyotis diffusa exert these herbs, through several uncertain processes to prevent the tumors from growing.

KEY WORDS: Tumor-inhibition, Components in herbs, .

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Paper presented at the International Symposium on the Impact of Biotechnology on Prediction, Prevention and Treatment of Cancer; Nice, France; October 24 - 27, 1998; in the section on Primary Prevention.